Perfil clínico y resultados de la hormonoterapia de reemplazo en la población hospitalaria uruguaya

Rafael Aguirre

Authors

Rafael Aguirre Universidad de la República, Facultad de Medicina, Centro Hospitalario Pereira Rossell, Hospital de la Mujer, Clínica Ginecotocológica "C", Asistente

Keywords:

ESTROGEN REPLACEMENT THERAPY, CLIMACTERIC, MENOPAUSE, LONGITUDINAL STUDIES, URUGUAY

Abstract

Perimenopausal alterations constitute nowadays an important public health issue. Hormone replacement therapy (HRT) has allowed treating perimenopausal symptoms and preventing long-term outcome due to hormonal deficiency.
Objective: to optimize HRT in Public Health users (Ministerio de Salud Pública, MSP) through the analysis of its characteristics and results.
Methods: we undertook a longitudinal, observational and prospective study. Two-side analysis and a level of 5% by means of t-test for independent samples and paired t-test for matched data according to the variable in question were used.
Results: characteristics of Uruguayan population did not differ from those described by international studies. A statistical significant change of clinical symptoms occurred, lipid profile improved and body weight lightly was increased with HRT. Only 5% of the studied women were excluded because of side effects. One third of the population stopped treatment without medical indication.
Conclusions: public Health users presented adequate tolerance, clinical and paraclinical responses to HRT. Accurate information and continue drug availability is needed in order to improve accessibility and completion of a therapy mainly based on prevention.

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