Occurrence of autoimmune phenomena in persons infected with HIV
Keywords:
HIV INFECTIONS, AUTOIMMUNE DISEASESAbstract
The etiology of autoimmune systemic diseases is still unknown. Human retroviruses are suspected of involvement in them. HIV infection and the immune reconstitution inflammatory syndrome have been associated to the develo-pment of antiphospholipid syndrome, systemic lupus erythematosus (SLE), Sjögren syndrome and systemic vasculitis, among other conditions.
We present two clinical cases that share the presence of autoimmune manifestations within the context of HIV infections.
References
(1) Douvas A, Takehana Y, Ehresmann G, Chernyovskiy T, Daar ES. Neutralization of HIV type 1 infectivity by serum antibodies from a subset of autoimmune in patients with mixed connective tissue disease. AIDS Res Hum Retroviruses 1996; 12(16): 1509-17.
(2) Brancato L, Itescu S, Skovron ML, Solomon G, Winchester R. Aspects of the spectrum, prevalence and disease susceptibility determinants of Reiter’s syndrome and related disorders associated with HIV infection. Rheumatol Int 1989; 9(3-5): 137-41.
(3) Medina-Rodriguez F, Guzman C, Jara LJ, Hermida C, Alboukrek D, Cervera H, et al. Rheumatic manifestations in human immunodeficiency virus positive and negative individuals: a study of 2 populations with similar risk factors. J Rheumatol 1993; 20(11): 1880-4.
(4) Bloom EJ, Abrams DI, Rodgers G. Lupus anticoagulant in the acquired immunodeficiency syndrome. JAMA 1986; 256(4): 491-3.
(5) de Clerck LS, Couttenye MM, de Broe ME, Stevens WJ. Acquired immunodeficiency syndrome mimicking Sjögren’s syndrome and systemic lupus erythematosus. Arthritis Rheum 1988; 31(2): 272-5.
(6) Calabrese LH, Kirchner E, Shrestha R. Rheumatic complications of human immunodeficiency virus infection in the era of highly active antiretroviral therapy: emergence of a new syndrome of immune reconstitution and changing patterns of disease. Semin Arthritis Rheum 2005; 35(3): 166-74.
(7) Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4(2): 295-306. .
(8) Petrovas C, Vlachoyiannopoulos PG, Kordossis T, Moutsopoulos HM. Antiphospholipid antibodies in HIV infection and SLE with or without antiphospholipid syndrome: comparisons phospholipids specificity, avidity and reactivity with beta 2-GPI. J Autoimmun 1999; 13(3): 347-55.
(9) Cervera R, Asherson RA, Acevedo ML, Gómez-Puerta JA, Espinosa G, De La Red G, et al. Antiphospholipid syndrome associated with infections: clinical and microbiological characteristics of 100 patients. Ann Rheum Dis 2004; 63(10): 1312-7.
(10) Awodu OA, Olayemi EE, Bazuaye GN, Onunu AN. Lupus anticoagulant in human immunodeficiency virus-infected patients on highly active antiretroviral therapy. Indian J Pathol Microbiol 2010; 53(1):47-9. Disponible en: http://www.ijpmonline.org/article.asp?issn=0377-4929; year=2010;volume=53;issue=1;spage=47;epage=49;aulast=Awodu. Consulta: 16 abril 2010.
(11) Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40(9):1725.
(12) Sekigawa I, Ogasawara H, Kaneko H, Hishikawa T, Hashimoto H. Retroviruses and autoimmunity. Int Med 2001; 40(2): 80-6.
(13) Povolotsky J, Polsky B, Laurence J, Jindal R, Rozon-Solomon M, Burrows L. Withdrawal of conclusion: false positive tests for HIV in a woman with lupus. N Engl J Med 1994; 331(13): 881-2.
(14) Kulthanan K, Jiamton S, Omcharoen V, Linpiyawan R, Ruangpeerakul J, Sivayathorn A. Autoimmune and rheumatic manifestations and antinuclear antibody study in HIV-infected Thai patients. Int J Dermatol 2002; 41(7): 417-22.
(15) Savige JA, Chang L, Horn S, Crowe SM. Anti-nuclear, anti-neutrophil cytoplasmic and anti-glomerular basement membrane antibodies in HIV-infected individuals. Autoimmunity 1994; 18(3): 205-11.
(2) Brancato L, Itescu S, Skovron ML, Solomon G, Winchester R. Aspects of the spectrum, prevalence and disease susceptibility determinants of Reiter’s syndrome and related disorders associated with HIV infection. Rheumatol Int 1989; 9(3-5): 137-41.
(3) Medina-Rodriguez F, Guzman C, Jara LJ, Hermida C, Alboukrek D, Cervera H, et al. Rheumatic manifestations in human immunodeficiency virus positive and negative individuals: a study of 2 populations with similar risk factors. J Rheumatol 1993; 20(11): 1880-4.
(4) Bloom EJ, Abrams DI, Rodgers G. Lupus anticoagulant in the acquired immunodeficiency syndrome. JAMA 1986; 256(4): 491-3.
(5) de Clerck LS, Couttenye MM, de Broe ME, Stevens WJ. Acquired immunodeficiency syndrome mimicking Sjögren’s syndrome and systemic lupus erythematosus. Arthritis Rheum 1988; 31(2): 272-5.
(6) Calabrese LH, Kirchner E, Shrestha R. Rheumatic complications of human immunodeficiency virus infection in the era of highly active antiretroviral therapy: emergence of a new syndrome of immune reconstitution and changing patterns of disease. Semin Arthritis Rheum 2005; 35(3): 166-74.
(7) Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4(2): 295-306. .
(8) Petrovas C, Vlachoyiannopoulos PG, Kordossis T, Moutsopoulos HM. Antiphospholipid antibodies in HIV infection and SLE with or without antiphospholipid syndrome: comparisons phospholipids specificity, avidity and reactivity with beta 2-GPI. J Autoimmun 1999; 13(3): 347-55.
(9) Cervera R, Asherson RA, Acevedo ML, Gómez-Puerta JA, Espinosa G, De La Red G, et al. Antiphospholipid syndrome associated with infections: clinical and microbiological characteristics of 100 patients. Ann Rheum Dis 2004; 63(10): 1312-7.
(10) Awodu OA, Olayemi EE, Bazuaye GN, Onunu AN. Lupus anticoagulant in human immunodeficiency virus-infected patients on highly active antiretroviral therapy. Indian J Pathol Microbiol 2010; 53(1):47-9. Disponible en: http://www.ijpmonline.org/article.asp?issn=0377-4929; year=2010;volume=53;issue=1;spage=47;epage=49;aulast=Awodu. Consulta: 16 abril 2010.
(11) Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40(9):1725.
(12) Sekigawa I, Ogasawara H, Kaneko H, Hishikawa T, Hashimoto H. Retroviruses and autoimmunity. Int Med 2001; 40(2): 80-6.
(13) Povolotsky J, Polsky B, Laurence J, Jindal R, Rozon-Solomon M, Burrows L. Withdrawal of conclusion: false positive tests for HIV in a woman with lupus. N Engl J Med 1994; 331(13): 881-2.
(14) Kulthanan K, Jiamton S, Omcharoen V, Linpiyawan R, Ruangpeerakul J, Sivayathorn A. Autoimmune and rheumatic manifestations and antinuclear antibody study in HIV-infected Thai patients. Int J Dermatol 2002; 41(7): 417-22.
(15) Savige JA, Chang L, Horn S, Crowe SM. Anti-nuclear, anti-neutrophil cytoplasmic and anti-glomerular basement membrane antibodies in HIV-infected individuals. Autoimmunity 1994; 18(3): 205-11.
Downloads
Published
2010-09-30
How to Cite
1.
Silvariño R, Cabrera S, Méndez E, Savio E. Occurrence of autoimmune phenomena in persons infected with HIV. Rev. Méd. Urug. [Internet]. 2010 Sep. 30 [cited 2024 Nov. 21];26(3):161-7. Available from: https://revista.rmu.org.uy/index.php/rmu/article/view/421
Issue
Section
Clinical Cases
