Cutaneous melanoma in Uruguay
Clinical and epidemiological survival in a cohort of patients assisted intwo reference centers between 2008-2017
DOI:
https://doi.org/10.29193/RMU.36.2.4Keywords:
MELANOMA, SKIN NEOPLASMS, SURVIVAL, URUGUAYAbstract
Cutaneous melanoma is the tumour whose incidence has increased the most in recent years. This condition is highly lethal in advanced stages. In our country the annual average of cases adds up to 129 in men and 117 in women, there being 50 and 30 respectively, every year.
Objective: to describe and analyse the clinical and epidemiological profile and survival in a cohort of patients who are carriers of cutaneous melanoma and were assisted in two reference centers in Montevideo between 2008 and 2017.
Methods: we conducted a descriptive, retrospective, observational study of historical cohorts, based on a review of the medical records in patients with a diagnosis of cutaneous melanoma assisted in the Oncology Service of the University Hospital and the Skin Oncology Unit of the National Cancer Institute between 2008 and 2017, with a follow-up until March 31, 2018.
Results: 173 pacientes were analysed, median age was 61.2 years old (14-89), 50.3% were men and 49.7% were women. Nodular anatomo-clinical presentation was the most frequent form (32.7%), followed by superficial spreading (28.9%), other forms being less frequent. Median global survival was not achieved, global survival after 5 years being 68.5% and 54.5% after 10 years. Median global survival in Stage 4 was 12 months (IC 95% 8.5-21.5).
Conclusions: the results in our series are similar to those reported internationally, in terms of global survival, the same as in most of the clinical an epidemiological characteristics. This is the first study with a cutaneous melanoma survival report in our country.
References
(1) Chang A, Karnell L, Menck H. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998; 83(8):1664-78.
(2) International Agency for Cancer Research. Global Cancer Observatory. Lyon: IARC, 2018. Disponible en: http://gco. iarc.fr/. [Consulta: 6 octubre 2018].
(3) Comisión Honoraria de Lucha Contra el Cáncer. Registro Nacional de Cáncer. Situación epidemiológica del Uruguay en relación al cáncer-Mayo 2019. Montevideo: CHLCC, 2019. Disponible en: http://www.comisioncancer.org.uy /uc_513_1.html. [Consulta: 2 noviembre 2019].
(4) Ribas A, Craig L, Slingluff JrR. Cutaneous Melanoma. En: Devita V, Lawrence T, Rosenberg S. Devita, Hellman and Rosenberg’s Cancer: principles & practice of Oncology. 10 ed. Philadelphia: Wolters-Kluwer, 2015:1990-2050.
(5) Enninga E, Moser J, Weaver A, Markovic S, Brewer J, Leontovich A, et al. Survival of cutaneous melanoma based on sex, age, and stage in the United States, 1992-2011. Cancer Med 2017; 6(10):2203-12.
(6) Katalinic A, Kunze U, Schäfer T. Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer). Br J Dermatol 2003; 149(6):1200-6.
(7) Fernández I, Rivas F, Fúnez R, Bámquez N, de Troya M. Epidemiología del melanoma en una población multicultural mediterránea. Piel 2014; 29(7):401-5.
(8) Iribarren O, Sepúlveda M, Hidalgo J, Madariaga J. Estudio epidemiológico de melanoma maligno en la IV Región de Chile. Cuad Cir 2005; 19(1):33-8.
(9) Pozzobon F, Fierro E, Acosta Á, Carreñoc A. Características del melanoma cutáneo primario en el Instituto Nacional de Cancerología 2006-2010. Rev Colomb Cancerol 2013; 17(3):111-8.
(10) Gutierrez C, Alarcón E, Valle R, Calderón G. Epidemiología del melanoma maligno en el Instituto Nacional de Enfermedades Neoplásicas , Perú , 2000-2004. Folia Dermatol Perú 2007; 18(1):23-7.
(11) Loria D, González A, Latorre C. Cutaneous melanoma epidemiology in Argentina?: analysis from the Argentine Cutaneous Melanoma Registry. Dermatol Argent 2008; 14(2):436-42.
(12) Ferrari N, Muller H, Ribeiro M, Maia M, Sanches J. Melanoma cutâneo: estudo epidemiológico descritivo. Sao Paulo Med J. 2008; 126(1):41-7.
(13) Bevona C, Goggins W, Quinn T, Fullerton J, Tsao H. Cutaneous melanomas associated with nevi. Arch Dermatol 2003; 139(12):1620-4.
(14) Damsky W, Bosenberg M. Melanocytic nevi and melanoma: unraveling a complex relationship. Oncogene 2017; 36(42):5771-92.
(15) Lin W, Luo S, Muzikansky A, Lobo A, Tanabe K, Sober A, et al. Outcome of patients with de novo versus nevus-associated melanoma. J Am Acad Dermatol 2015; 72(1):54-8.
(16) Duarte C, Flórez J, López H, Meneses M, de Vries E. Survival of acral lentiginous melanoma in the National Cancer Institute of Colombia. J Eur Acad Dermatol Venereol 2017; 31(3):438-442.
(17) Sáenz S, Conejo-Mir J, Cayuela A. Epidemiología del melanoma en España. Actas Dermosifiliogr 2005; 96(7):411-8.
(18) Ríos L, Nagore E, López J, Redondo P, Martí RM, Fernández-de-Misa R, et al. Registro nacional de melanoma cutáneo. Características del tumor en el momento del diagnóstico: 15 años de experiencia. Actas Dermosifiliogr 2013; 104(9):789-99.
(19) Bellolio E, San Martín A, Quiñiñir L, Orellana J, Tapia O, Rifo P, et al. Evaluación de factores histológicos pronósticos de sobrevida en melanoma maligno cutáneo, seguimiento de 13 años. Rev Chil Cir 2010; 62(4):331-8.
(20) Thomas N, Kricker A, Waxweiler W, Dillon P, Busman K, From L, et al. Comparison of clinicopathologic features and survival of histopathologically amelanotic and pigmented melanomas: a population-based study. JAMA Dermatol 2014; 150(12):1306-314.
(21) Elwood J, Gallagher R. Body site distribution of cutaneous malignant melanoma in relationship to patterns of sun exposure. Int J Cancer 1998; 78(3):276-80.
(22) Avilés-Izquierdo J, Lázaro-Ochaita P, Suárez-Fernández R, Márquez-Rodas I, Parra-Blanco V, Escat-Cortés J. Cambios epidemiológicos en el melanoma cutáneo: estudio retrospectivo de 969 casos (1996-2010). Rev Clin Esp 2013; 213(2):81-7.
(23) Schmerling R, Loria D, Cinat G, Ramos W, Cardona A, Sánchez J, et al. Cutaneous melanoma in Latin America: the need for more data. Rev Panam Salud Publica 2011; 30(5):431-8.
(24) Ascierto P, Kirkwood J, Grob J, Simeone E, Grimaldi A, Maio M, et al. The role of BRAF V600 mutation in melanoma. J Transl Med 2012; 10:85.
(25) Cheng L, Lopez-Beltran A, Massari F, MacLennan G, Montironi R. Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine. Mod Pathol 2018; 31(1):24-38.
(26) Morton D, Thompson J, Cochran A, Mozzillo N, Nieweg O, Roses D, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med 2014; 370(7):599-609.
(27) Mangana J, Cheng P, Kaufmann C, Amann V, Frauchiger A, Stögner V, et al. Multicenter, real-life experience with checkpoint inhibitors and targeted therapy agents in advanced melanoma patients in Switzerland. Melanoma Res 2017; 27(4):358-68.
(28) Sosman J, Moon J, Tuthill R, Warneke J, Vetto J, Redman B, et al. A phase 2 trial of complete resection for stage IV melanoma: results of Southwest Oncology Group Clinical Trial S9430. Cancer 2011; 117(20):4740-06.
(29) Jochems A, Schouwenburg M, Leeneman B, Franken M, van den Eertwegh A, Haanen J, et al. Dutch Melanoma Treatment Registry: quality assurance in the care of patients with metastatic melanoma in the Netherlands. Eur J Cancer 2017; 72:156-65.
(2) International Agency for Cancer Research. Global Cancer Observatory. Lyon: IARC, 2018. Disponible en: http://gco. iarc.fr/. [Consulta: 6 octubre 2018].
(3) Comisión Honoraria de Lucha Contra el Cáncer. Registro Nacional de Cáncer. Situación epidemiológica del Uruguay en relación al cáncer-Mayo 2019. Montevideo: CHLCC, 2019. Disponible en: http://www.comisioncancer.org.uy /uc_513_1.html. [Consulta: 2 noviembre 2019].
(4) Ribas A, Craig L, Slingluff JrR. Cutaneous Melanoma. En: Devita V, Lawrence T, Rosenberg S. Devita, Hellman and Rosenberg’s Cancer: principles & practice of Oncology. 10 ed. Philadelphia: Wolters-Kluwer, 2015:1990-2050.
(5) Enninga E, Moser J, Weaver A, Markovic S, Brewer J, Leontovich A, et al. Survival of cutaneous melanoma based on sex, age, and stage in the United States, 1992-2011. Cancer Med 2017; 6(10):2203-12.
(6) Katalinic A, Kunze U, Schäfer T. Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer). Br J Dermatol 2003; 149(6):1200-6.
(7) Fernández I, Rivas F, Fúnez R, Bámquez N, de Troya M. Epidemiología del melanoma en una población multicultural mediterránea. Piel 2014; 29(7):401-5.
(8) Iribarren O, Sepúlveda M, Hidalgo J, Madariaga J. Estudio epidemiológico de melanoma maligno en la IV Región de Chile. Cuad Cir 2005; 19(1):33-8.
(9) Pozzobon F, Fierro E, Acosta Á, Carreñoc A. Características del melanoma cutáneo primario en el Instituto Nacional de Cancerología 2006-2010. Rev Colomb Cancerol 2013; 17(3):111-8.
(10) Gutierrez C, Alarcón E, Valle R, Calderón G. Epidemiología del melanoma maligno en el Instituto Nacional de Enfermedades Neoplásicas , Perú , 2000-2004. Folia Dermatol Perú 2007; 18(1):23-7.
(11) Loria D, González A, Latorre C. Cutaneous melanoma epidemiology in Argentina?: analysis from the Argentine Cutaneous Melanoma Registry. Dermatol Argent 2008; 14(2):436-42.
(12) Ferrari N, Muller H, Ribeiro M, Maia M, Sanches J. Melanoma cutâneo: estudo epidemiológico descritivo. Sao Paulo Med J. 2008; 126(1):41-7.
(13) Bevona C, Goggins W, Quinn T, Fullerton J, Tsao H. Cutaneous melanomas associated with nevi. Arch Dermatol 2003; 139(12):1620-4.
(14) Damsky W, Bosenberg M. Melanocytic nevi and melanoma: unraveling a complex relationship. Oncogene 2017; 36(42):5771-92.
(15) Lin W, Luo S, Muzikansky A, Lobo A, Tanabe K, Sober A, et al. Outcome of patients with de novo versus nevus-associated melanoma. J Am Acad Dermatol 2015; 72(1):54-8.
(16) Duarte C, Flórez J, López H, Meneses M, de Vries E. Survival of acral lentiginous melanoma in the National Cancer Institute of Colombia. J Eur Acad Dermatol Venereol 2017; 31(3):438-442.
(17) Sáenz S, Conejo-Mir J, Cayuela A. Epidemiología del melanoma en España. Actas Dermosifiliogr 2005; 96(7):411-8.
(18) Ríos L, Nagore E, López J, Redondo P, Martí RM, Fernández-de-Misa R, et al. Registro nacional de melanoma cutáneo. Características del tumor en el momento del diagnóstico: 15 años de experiencia. Actas Dermosifiliogr 2013; 104(9):789-99.
(19) Bellolio E, San Martín A, Quiñiñir L, Orellana J, Tapia O, Rifo P, et al. Evaluación de factores histológicos pronósticos de sobrevida en melanoma maligno cutáneo, seguimiento de 13 años. Rev Chil Cir 2010; 62(4):331-8.
(20) Thomas N, Kricker A, Waxweiler W, Dillon P, Busman K, From L, et al. Comparison of clinicopathologic features and survival of histopathologically amelanotic and pigmented melanomas: a population-based study. JAMA Dermatol 2014; 150(12):1306-314.
(21) Elwood J, Gallagher R. Body site distribution of cutaneous malignant melanoma in relationship to patterns of sun exposure. Int J Cancer 1998; 78(3):276-80.
(22) Avilés-Izquierdo J, Lázaro-Ochaita P, Suárez-Fernández R, Márquez-Rodas I, Parra-Blanco V, Escat-Cortés J. Cambios epidemiológicos en el melanoma cutáneo: estudio retrospectivo de 969 casos (1996-2010). Rev Clin Esp 2013; 213(2):81-7.
(23) Schmerling R, Loria D, Cinat G, Ramos W, Cardona A, Sánchez J, et al. Cutaneous melanoma in Latin America: the need for more data. Rev Panam Salud Publica 2011; 30(5):431-8.
(24) Ascierto P, Kirkwood J, Grob J, Simeone E, Grimaldi A, Maio M, et al. The role of BRAF V600 mutation in melanoma. J Transl Med 2012; 10:85.
(25) Cheng L, Lopez-Beltran A, Massari F, MacLennan G, Montironi R. Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine. Mod Pathol 2018; 31(1):24-38.
(26) Morton D, Thompson J, Cochran A, Mozzillo N, Nieweg O, Roses D, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med 2014; 370(7):599-609.
(27) Mangana J, Cheng P, Kaufmann C, Amann V, Frauchiger A, Stögner V, et al. Multicenter, real-life experience with checkpoint inhibitors and targeted therapy agents in advanced melanoma patients in Switzerland. Melanoma Res 2017; 27(4):358-68.
(28) Sosman J, Moon J, Tuthill R, Warneke J, Vetto J, Redman B, et al. A phase 2 trial of complete resection for stage IV melanoma: results of Southwest Oncology Group Clinical Trial S9430. Cancer 2011; 117(20):4740-06.
(29) Jochems A, Schouwenburg M, Leeneman B, Franken M, van den Eertwegh A, Haanen J, et al. Dutch Melanoma Treatment Registry: quality assurance in the care of patients with metastatic melanoma in the Netherlands. Eur J Cancer 2017; 72:156-65.
Downloads
Published
2020-04-21
How to Cite
1.
Amarillo D, De Boni D, Nantes F, Tambasco C, Brayer C, Palacios C, et al. Cutaneous melanoma in Uruguay: Clinical and epidemiological survival in a cohort of patients assisted intwo reference centers between 2008-2017. Rev. Méd. Urug. [Internet]. 2020 Apr. 21 [cited 2024 Sep. 16];36(2):146-54. Available from: https://revista.rmu.org.uy/index.php/rmu/article/view/530
Issue
Section
Original Articles
