Assessment of iodine nutritional status in a pregnant women population

Authors

  • Soledad Bottaro Universidad de la República, Facultad de Medicina, Clínica Ginecotocológica A. Ex Asistente
  • Fernanda Gómez Universidad de la República, Facultad de Medicina, Clínica Ginecotocológica A. Prof. Adj (i)
  • Agustina Franciulli Universidad de la República, Facultad de Medicina, Clínica Ginecotocológica A. Médico Residente
  • Eloísa Capano Universidad de la República, Facultad de Medicina, Clínica Ginecotocológica A. Médico Residente
  • Soledad Rodríguez Universidad de la República, Facultad de Química, Alimentos y Nutrición, IPTP. Ayudante (i)
  • Caterina Rufo Universidad de la República, Facultad de Química, Alimentos y Nutrición, IPTP. Prof. Adj (i)
  • Paulina Castiglioni Licenciada en Nutrición
  • Giselle Tomaso Universidad de la República, Facultad de Medicina, Clínica Ginecotocológica A. Ex Prof. Adj (i)
  • Francisco Cóppola Universidad de la República, Facultad de Medicina, Clínica Ginecotocológica A. Prof. Agdo

Keywords:

IODINE DEFICIENCY, PREGNANCY, DIETARY SUPPLEMENTS, IODINE

Abstract

Introduction: iodine deficit in pregnant women may have a negative effect on the mother and the newborn, and it is associated to several obstetric complications such as spontaneous abortion, fetal death, congenital anomalies, increase of perinatal mortality and cretinism.
The World Health Organization (WHO) establishes that iodine deficit is still the main global avoidable cause for mental retardation and brain palsy, and it affects the development and wellbeing of millions of people around the world at different levels. Pregnant women are a vulnerable population with high requirements.
No studies in the pregnant women population have been conducted in Uruguay after the universal salt iodation in 1999.
Main objective: assessment of iodine nutritional condition in a pregnant women population.
Secondary objective: to obtain a qualitative impression of the possible sources of nutritional iodine in this population.
Methods: a specially prepared nutritional survey was conducted and first morning urine samples were collected to determine ioduria in pregnant women, regardless of the trimester. In this population, iodine deficiency was defined for this population when urine excretion was below 150 ?g/l (WHO, 2007).
Results: ninety six urine samples were analysed. Median of the average urinary excretion for this population was 182 ?g/l, normal rates being between 150 and 249 ?g/l.
Conclusions: the study confirmed iodine urinary excretion lies within the adequate range established by the WHO.

References

(1) de Benoist B, Andersson M, Takkouche B, Egli I. Prevalence of iodine deficiency worldwide. Lancet 2003; 362(9398):1859-60.
(2) World Health Organization. Assessment of the iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3 ed. Geneva: WHO, 2007.
(3) Zimmermann MB. The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review. Thyroid 2007; 17(9):829-35.
(4) Bath SC, Steer CD, Golding J, Emmett P, Rayman MP. Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Lancet 2013; 382(9889):331-7.
(5) Delange F. The disorders induced by iodine deficiency. Thyroid 1994; 4(1):107-28.
(6) Pharoah PO, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet 1971; 1(7694):308-10.
(7) Pharoah PO, Connolly KJ. A controlled trial of iodinated oil for the prevention of endemic cretinism: a long-term follow-up. Int J Epidemiol 1987; 16(1):68-73.
(8) Thilly C, Lagasse R, Roger G, Bourdoux P, Ermans AM. Impaired fetal and postnatal development and high perinatal death rate in a severe iodine deficient area. En: Stockigt JR, Nagataki S, Meldrum E, Barlow JW, Harding PE, eds..Thyroid research VIII. Canberra, Australia: Australian Academy of Science, 1980:20–3.
(9) Thilly CH, Swennen B, Moreno-Reyes R, Hindlet JY, Bourdoux P, Vanderoas JB. Maternal, fetal and juvenile hypothyroidism, birth weight and infant mortality in the etiopathogenesis of the IDD spectrum in Zaire and Malawi. In: Stanbury JB, ed. The damaged brain of iodine deficiency. New York, NY: Cognizant Communication, 1994: 241–50.
(10) Cao XY, Jiang XM, Dou ZH, Rakeman MA, Zhang ML, O’Donnell K, et al. Timing of vulnerability of the brain to iodine deficiency in endemic cretinism. N Engl J Med 1994; 331(26):1739-44.
(11) Pretell EA, Caceres A. Impairment of mental development by iodine deficiency and its correction: a retrospective view of studies in Peru. En: Stanbury JB, ed. The damaged brain of iodine deficiency. New York, NY: Cognizant Communication, 1994:187–91.
(12) Fierro-Benitez R, Cazar R, Stanbury JB, Rodriguez P, Garces F, Fierro-Renoy F, et al. Effects on school children of prophylaxis of mothers with iodized oil in an area of iodine deficiency. J Endocrinol Invest 1988; 11(5):327-35.
(13) Zimmermann MB. Iodine deficiency. Endocr Rev 2009; 30(4):376-408.
(14) Queiruga G, Revello M, Maggiolo J, Salveraglio C, Morales A. Yodurias en la población del Uruguay: Premio Metec – Supac. En: V Congreso Uruguayo de Patología Clínica, IMM, Montevideo, 1994.
(15) Queiruga G, Revello M, Maggiolo J, Salveraglio C, Morales A. Yodurias en la población del Uruguay: patología Clínica. Rev Asoc Quím Farm Urug 1994; 11:26-30.
(16) Revello M, Queiruga G, Morales A, Salveraglio C, Maggiolo J. Metabolismo del yodo en embarazadas que no ingerían sal yodada. Prensa Méd Urug 1999; 20:9-15.
(17) Queiruga G, Rocca A, Salveraglio C, Maggiolo J. Yodurias en la población del Uruguay y su relación con la TSH Neonatal. En: Memorias del V Congreso Latinoamericano de Errores Innatos del Metabolismo y Pesquisa Neonatal, 8-10 Nov., San José de Costa Rica. 2005.
(18) Pregnancyiodine: encuesta alimenticia. Blog. Disponible en: http://pregnancyiodine.blogspot.com.uy/2016/05/encuesta-alimenticia.html. Consulta: 4 mayo 2016.
(19) Pregnancyiodine: fármacos que contiene yodo. Blog. Disponible en: http://pregnancyiodine.blogspot.com.uy/2016/ 05/farmacos-que-contienen-yodo.html. Consulta: 4 mayo 2016.
(20) Ohashi T, Yamaki M, Pandav CS, Karmarkar MG, Irie M. Simple microplate method for determination of urinary iodine. Clin Chem 2000; 46(4):529-36.
(21) Sandell EB, Kolthoff IM. Micro determination of iodine by catalytic method. Mikrochemica Acta 1937; 1: 9-25.
(22) 22. Clifton VL, Hodyl NA, Fogarty PA, Torpy DJ, Roberts R, Nettelbeck T, et al. The impact of iodine supplementation and bread fortification on urinary iodine concentrations in a mildly iodine deficient population of pregnant women in South Australia. Nutr J 2013; 12:32.

Published

2016-09-30

How to Cite

1.
Bottaro S, Gómez F, Franciulli A, Capano E, Rodríguez S, Rufo C, et al. Assessment of iodine nutritional status in a pregnant women population. Rev. Méd. Urug. [Internet]. 2016 Sep. 30 [cited 2024 Nov. 21];32(3):152-8. Available from: https://revista.rmu.org.uy/index.php/rmu/article/view/163

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