Performance of the Bethesda SYSTEM in the cytopathological diagnosis of the thyroid nodule in a university center (Hospital de Clínicas) in Uruguay, ten years of experience

Authors

  • Carolina Guarneri Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Clínica Quirúrgica “A”, Cirugía General, Asistente
  • Ulises Parada Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Clínica Quirúrgica “A”, Cirugía General, Asistente
  • Lucía Fernández Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Clínica Quirúrgica “A”, Cirugía General, Residente
  • Roberto Taruselli Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Clínica Quirúrgica “A, Cirugía General, Profesor Agregado
  • Luis Cazabán Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Clínica Quirúrgica “A”, Profesor Director

DOI:

https://doi.org/10.29193/RMU.38.2.7

Keywords:

BETHESDA SYSTEM, RISK OF MALIGNANCY, CYTOPATHOLOGICAL CORRELATION

Abstract

Introduction: the ultrasound-guided fine needle aspiration biopsy (FNAB) study is characterized by being fast, reliable, minimally invasive, and cost-effective. It reduces unnecessary surgical procedures and appropriately classifies patients with suspicious or malignant nodules for timely surgical intervention.
Objective: the objective of this study is to evaluate the cytological-pathological correlation of the Bethesda System in a university center (Hospital de Clínicas) in Uruguay.
Methodology: an observational, retrospective, descriptive study was carried out, based on the analysis of medical records of patients undergoing thyroid surgery at the Hospital de Clínicas, in the period between January 2008 and December 2018.
Results: of the initial total of 119 patients, 93 met the inclusion criteria. The age range of the sample was between 15 and 79 years. Of the total of punctured, 49.5% (46) were reported as benign and 50.5% (47) as malignant.
A sensitivity of 96% (0.96) with CI 1.0-0.90, specificity of 98% (0.97) with CI 1.0-0.93, a PPV of 98% and NPV of 96%.
The diagnostic sensitivity for categories IV, V and VI was 96% with a specificity of 100, 94 and 100% respectively.
Conclusions: the Bethesda system applied to FNA of thyroid nodules enhances diagnostic certainty and assists in the therapeutic decision. In our institution we have a good cytopathological correlation, similar to other works reported in the literature. This makes it possible to adequately predict the risk of malignancy and facilitate decision-making.

References

1) Burman KD, Wartofsky L. Clinical practice. Thyroid nodules. N Engl J Med 2015; 373(24):2347-56.
2) Guth S, Theune U, Aberle J, Galach A, Bamberger CM. Very high prevalence of thyroid nodules detectedby high frequency (13 MHz) ultrasound examination. Eur J Clin Invest 2009; 39(8):699-706.
3) Perri F, Giordano A, Pisconti S, Ionna F, Chiofalo MG, Longo F, et al. Thyroid cancer management: from a suspicious nodule to targeted therapy. Anticancer Drugs 2018; 29(6):483-90.
4) Triantafillou E, Papadakis G, Kanouta F, Kalaitzidou S, Drosou A, Sapera A, et al. Thyroid ultrasonographic charasteristics and Bethesda results after FNAB. J BUON 2018; 23(7):139-43.
5) Fernández Sánchez J. Clasificación TI-RADS de los nódulos tiroideos en base a una escala de puntuación modificada con respecto a los criterios ecográficos de malignidad. Rev Argentina Radiol 2014; 78(3):138-48.
6) Eszlinger M, Lau L, Ghaznavi S, Symonds C, Chandarana SP, Khalil M, et al. Molecular profiling of thyroid nodule fine-needle aspiration cytology. Nat Rev Endocrinol 2017; 13(7):415-24.
7) Rodríguez González H, Pava Marín R, Castaño Herrera LF, Valencia García LV, Pava Ripoll AE. Evaluación de la precisión diagnóstica de la punción aspiración con aguja fina en pacientes con nódulo tiroideo. Biosalud 2017; 16(1):11-8.
8) Cibas ES, Ali SZ. The 2017 Bethesda System for Reporting Thyroid Cytopathology. Thyroid 2017; 27(11):1341-6.
9) Syed Z. Ali. Thyroid cytopathology: Bethesda and beyond. Acta Cytol 2011; 55(1):4-12.
10) Gunes P, Canberk S, Onenerk M, Erkan M, Gursan N, Kilinc E, et al. A different perspective on evaluating the malignancy rate of the non-diagnostic category of the Bethesda system for reporting thyroid cytopathology: a single institute experience and review of the literature. PLoS One 2016; 11(9):1-10.
11) Cibas ES, Baloch ZW, Fellegara G, Livolsi VA, Raab SS, Rosai J, et al. A prospective assessment defining the limitations of thyroid nodule pathologic evaluation. Ann Intern Med 2013; 159(5):325-32.
12) Bongiovanni M, Spitale A, Faquin WC, Mazzucchelli L, Baloch ZW. The Bethesda System For Reporting Thyroid Cytopathology: a meta-analysis. Acta Cytol 2012; 56(4):333-9.
13) Granel-Villacha L, Fortea-Sanchis C, Laguna-Sastre JM, Escrig-Sos J. Performance of the Bethesda system in the citopathological diagnosis of the thyroid nodule. Cir Esp (Engl Ed) 2018; 96(6):599-600.
14) Murillo M, Palta A, Patiño G. Prueba diagnóstica entre la citología, biopsia por congelación e histopatología en el diagnóstico del nódulo tiroideo en pacientes atendidos en Solca desde el año 2009-2017. Rev Oncol Ecu 2020; 30(3):204-14. doi: https://doi.org/10.
15) Kholová I, Haaga E, Ludvik J, Kalfert D, Ludvikova M. Noninvasive Follicular Thyroid Neoplasm with Papillary-like nuclear features (niftp): tumour entity with a short history. A review on challenges in our microscopes, molecular and ultrasonographic profile. Diagnostics (Basel) 2022; 12(2):250.
16) Rodríguez-González M, González-Velasco C, Gómez-Muñóz MA, Sayagués-Manzano JM, Ludeña-de-la-Cruz MD. Cómo mejorar la precisión de los diagnósticos I y III del Sistema Bethesda. Revista ORL 2021; 12(4):303-12. doi: 10.14201/orl.25005.
17) Asa SL. The role of immunohistochemical markers in the diagnosis of follicular-patterned lesions of the thyroid. Endocr Pathol 2005; 16(4):295-309.
18) Baca SC, Wong KS, Strickland KC, Heller HT, Kim MI, Barletta JA, et al. Qualifiers of atypia in the cytologic diagnosis of thyroid nodules are associated with different Afirma gene expression classifier results and clinical outcomes. Cancer Cytopathol 2017; 125(5):313-22.

Published

2022-08-08

How to Cite

1.
Guarneri C, Parada U, Fernández L, Taruselli R, Cazabán L. Performance of the Bethesda SYSTEM in the cytopathological diagnosis of the thyroid nodule in a university center (Hospital de Clínicas) in Uruguay, ten years of experience. Rev. Méd. Urug. [Internet]. 2022 Aug. 8 [cited 2024 Sep. 7];38(2):e38208. Available from: https://revista.rmu.org.uy/index.php/rmu/article/view/891