Severe adenovirus infections in hepatic transplant recipients
DOI:
https://doi.org/10.29193/RMU.38.1.14Keywords:
ADENOVIRIDAE, LIVER TRANSPLANTATION, IMMUNOSUPPRESSED PATIENTSAbstract
Human adenoviruses still constitute a challenge in the clinical practice. These are DNA viruses that are widely disseminated among the population and often cause self-limiting diseases in children. However, it may result in a severe diseminated disease with high morbi-mortality rates in immunocompromised patients, in particular transplant recipients of hematopoietic cells and solid organs. The study shares the first national report for disseminated adenovirus disease, presenting two clinical cases of hepatic transplant recipients who developed severe disseminated adenovirus disease. And conducting a literature review on the topic.
References
1) Stephenson K, Rhee E, Barouch D. Adenoviruses. En: Bennett J, Dolin R, Blaser M, eds. Mandell, Douglas and Bennett´s prin-ciples and practice of infectious diseases. Philadelphia: Elsevier, 2020:1908-15.e3
2) Robinson C, Singh G, Lee J, Dehghan S, Rajaiya J, Liu E, et al. Molecular evolution of human adenoviruses. Sci Rep 2013; 3:1812. doi: 10.1038/srep01812.
3) Huang G, Xu W. Recent advance in new types of human ade-novirus. Bing Du Xue Bao 2013; 29(3):342-8.
4) Lion T. Adenovirus infections in immunocompetent and im-munocompromised patients. Clin Microbiol Rev 2014; 27(3):441-62. doi: 10.1128/CMR.00116-13.
5) Nanmoku K, Ishikawa N, Kurosawa A, Shimizu T, Kimura T, Miki A, et al. Clinical characteristics and outcomes of adenovirus in-fection of the urinary tract after renal transplantation. Transpl Infect Dis 2016; 18(2):234-9. doi: 10.1111/tid.12519.
6) Li Z, Chen Z, Chen L, Zhan Y, Li S, Cheng J, et al. Coinfection with SARS-CoV-2 and other respiratory pathogens in patients with COVID-19 in Guangzhou, China. J Med Virol 2020; 92(11):2381-3. doi: 10.1002/jmv.26073.
7) Motta J, Gómez C. Adenovirus and novel coronavirus (SARS-Cov2) coinfection: a case report. IDCases 2020; 22:e00936. doi: 10.1016/j.idcr.2020.e00936.
8) Nowak M, Sordillo E, Gitman M, Paniz Mondolfi A. Coinfection in SARS-CoV-2 infected patients: where are influenza virus and rhinovirus/enterovirus? J Med Virol 2020; 92(10):1699-700. doi: 10.1002/jmv.25953.
9) Munoz F, Piedra P, Demmler G. Disseminated adenovirus disea-se in immunocompromised and immunocompetent children. Clin Infect Dis 1998; 27(5):1194-200. doi: 10.1086/514978.
10) Berk A. Adenoviridae: the viruses and their replication. En: Fields B, Knipe D, Howley P, eds. Fields virology. Philadel-phia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2013:1704-31.
11) Hoffman J. Adenovirus infections in solid organ transplant recipients. Curr Opin Organ Transplant 2009; 14(6):625-33. doi: 10.1097/MOT.0b013e3283324e1b.
12) Nanmoku K, Ishikawa N, Kurosawa A, Shimizu T, Kimura T, Miki A, et al. Clinical characteristics and outcomes of adenovi-rus infection of the urinary tract after renal transplantation. Transpl Infect Dis. 2016 Apr;18(2):234-9. doi: 10.1111/tid.12519.
13) Kosulin K, Geiger E, Vécsei A, Huber W, Rauch M, Bren-ner E, et al Persistence and reactivation of human adenoviruses in the gastrointestinal tract. Clin Microbiol Infect 2016; 22(4):381.e1-e8. doi: 10.1016/j.cmi.2015.12.013.
14) Michaels M, Green M, Wald E, Starzl T. Adenovirus infec-tion in pediatric liver transplant recipients. J Infect Dis 1992; 165(1):170-4. doi: 10.1093/infdis/165.1.170.
15) de Mezerville M, Tellier R, Richardson S, Hébert D, Doyle J, Allen U. Adenoviral infections in pediatric transplant reci-pients: a hospital-based study. Pediatr Infect Dis J 2006; 25(9):815-8. doi: 10.1097/01.inf.0000233542.48267.fd.
16) Pinchoff R, Kaufman S, Magid M, Erdman D, Gondolesi G, Mendelson M, et al. Adenovirus infection in pediatric small bo-wel transplantation recipients. Transplantation 2003; 76(1):183-9. doi: 10.1097/01.TP.0000072808.93060.0F.
17) Gu J, Su Q, Zuo T, Chen Y. Adenovirus diseases: a sys-tematic review and meta-analysis of 228 case reports. Infection 2021; 49(1):1-13. doi: 10.1007/s15010-020-01484-7.
18) Florescu D, Schaenman J. Adenovirus in solid organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant 2019; 33(9):e13527. doi: 10.1111/ctr.13527.
19) Lion T. Adenovirus persistence, reactivation, and clinical management. FEBS Lett 2019; 593(24):3571-82. doi: 10.1002/1873-3468.13576.
20) Bonot S, Ogorzaly L, El Moualij B, Zorzi W, Cauchie H. Detection of small amounts of human adenoviruses in stools: comparison of a new immuno real-time PCR assay with classical tools. Clin Microbiol Infect 2014; 20(12):O1010-6. doi: 10.1111/1469-0691.12768.
21) Song E, Wang H, Salamon D, Jaggi P, Leber A. Perfor-mance characteristics of FilmArray Respiratory Panel v1.7 for detection of adenovirus in a large cohort of pediatric nasop-haryngeal samples: one test may not fit all. J Clin Microbiol 2016; 54(6):1479-86. doi: 10.1128/JCM.00143-16.
22) Watcharananan S, Avery R, Ingsathit A, Malathum K, Chantratita W, Mavichak V, et al. Adenovirus disease after kid-ney transplantation: course of infection and outcome in relation to blood viral load and immune recovery. Am J Transplant 2011; 11(6):1308-14. doi: 10.1111/j.1600-6143.2011.03479.x.
23) Gniadek T, Forman M, Martin I, Arav-Boger R, Valsamakis A. The effect of a genetic variant on quantitative real-time PCR in a case of disseminated adenovirus infection. Diagn Microbiol Infect Dis 2017; 89(1):40-3. doi: 10.1016/j.diagmicrobio.2017.05.013.
24) Leruez-Ville M, Minard V, Lacaille F, Buzyn A, Abachin E, Blanche S, et al. Real-time blood plasma polymerase chain reaction for management of disseminated adenovirus infection. Clin Infect Dis 2004; 38(1):45-52. doi: 10.1086/380450.
25) Guerra Sánchez C, Lorica C, Arheart K, Perez M, Tekin A, Gonzalez I. Virologic response with 2 different cidofovir dosing regimens for preemptive treatment of adenovirus DNAemia in pediatric solid organ transplant recipients. Pediatr Transplant 2018:e13231. doi: 10.1111/petr.13231.
26) Lankester A, Heemskerk B, Claas E, Schilham M, Beersma M, Bredius R, et al. Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection. Clin In-fect Dis 2004; 38(11):1521-5. doi: 10.1086/420817.
27) López S, Michaels M, Green M. Adenovirus infection in pediatric transplant recipients: are effective antiviral agents coming our way? Curr Opin Organ Transplant 2018; 23(4):395-9. doi: 10.1097/MOT.0000000000000542.
28) Ljungman P. Treatment of adenovirus infections in the immunocompromised host. Eur J Clin Microbiol Infect Dis 2004; 23(8):583-8. doi: 10.1007/s10096-004-1165-x.
2) Robinson C, Singh G, Lee J, Dehghan S, Rajaiya J, Liu E, et al. Molecular evolution of human adenoviruses. Sci Rep 2013; 3:1812. doi: 10.1038/srep01812.
3) Huang G, Xu W. Recent advance in new types of human ade-novirus. Bing Du Xue Bao 2013; 29(3):342-8.
4) Lion T. Adenovirus infections in immunocompetent and im-munocompromised patients. Clin Microbiol Rev 2014; 27(3):441-62. doi: 10.1128/CMR.00116-13.
5) Nanmoku K, Ishikawa N, Kurosawa A, Shimizu T, Kimura T, Miki A, et al. Clinical characteristics and outcomes of adenovirus in-fection of the urinary tract after renal transplantation. Transpl Infect Dis 2016; 18(2):234-9. doi: 10.1111/tid.12519.
6) Li Z, Chen Z, Chen L, Zhan Y, Li S, Cheng J, et al. Coinfection with SARS-CoV-2 and other respiratory pathogens in patients with COVID-19 in Guangzhou, China. J Med Virol 2020; 92(11):2381-3. doi: 10.1002/jmv.26073.
7) Motta J, Gómez C. Adenovirus and novel coronavirus (SARS-Cov2) coinfection: a case report. IDCases 2020; 22:e00936. doi: 10.1016/j.idcr.2020.e00936.
8) Nowak M, Sordillo E, Gitman M, Paniz Mondolfi A. Coinfection in SARS-CoV-2 infected patients: where are influenza virus and rhinovirus/enterovirus? J Med Virol 2020; 92(10):1699-700. doi: 10.1002/jmv.25953.
9) Munoz F, Piedra P, Demmler G. Disseminated adenovirus disea-se in immunocompromised and immunocompetent children. Clin Infect Dis 1998; 27(5):1194-200. doi: 10.1086/514978.
10) Berk A. Adenoviridae: the viruses and their replication. En: Fields B, Knipe D, Howley P, eds. Fields virology. Philadel-phia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2013:1704-31.
11) Hoffman J. Adenovirus infections in solid organ transplant recipients. Curr Opin Organ Transplant 2009; 14(6):625-33. doi: 10.1097/MOT.0b013e3283324e1b.
12) Nanmoku K, Ishikawa N, Kurosawa A, Shimizu T, Kimura T, Miki A, et al. Clinical characteristics and outcomes of adenovi-rus infection of the urinary tract after renal transplantation. Transpl Infect Dis. 2016 Apr;18(2):234-9. doi: 10.1111/tid.12519.
13) Kosulin K, Geiger E, Vécsei A, Huber W, Rauch M, Bren-ner E, et al Persistence and reactivation of human adenoviruses in the gastrointestinal tract. Clin Microbiol Infect 2016; 22(4):381.e1-e8. doi: 10.1016/j.cmi.2015.12.013.
14) Michaels M, Green M, Wald E, Starzl T. Adenovirus infec-tion in pediatric liver transplant recipients. J Infect Dis 1992; 165(1):170-4. doi: 10.1093/infdis/165.1.170.
15) de Mezerville M, Tellier R, Richardson S, Hébert D, Doyle J, Allen U. Adenoviral infections in pediatric transplant reci-pients: a hospital-based study. Pediatr Infect Dis J 2006; 25(9):815-8. doi: 10.1097/01.inf.0000233542.48267.fd.
16) Pinchoff R, Kaufman S, Magid M, Erdman D, Gondolesi G, Mendelson M, et al. Adenovirus infection in pediatric small bo-wel transplantation recipients. Transplantation 2003; 76(1):183-9. doi: 10.1097/01.TP.0000072808.93060.0F.
17) Gu J, Su Q, Zuo T, Chen Y. Adenovirus diseases: a sys-tematic review and meta-analysis of 228 case reports. Infection 2021; 49(1):1-13. doi: 10.1007/s15010-020-01484-7.
18) Florescu D, Schaenman J. Adenovirus in solid organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant 2019; 33(9):e13527. doi: 10.1111/ctr.13527.
19) Lion T. Adenovirus persistence, reactivation, and clinical management. FEBS Lett 2019; 593(24):3571-82. doi: 10.1002/1873-3468.13576.
20) Bonot S, Ogorzaly L, El Moualij B, Zorzi W, Cauchie H. Detection of small amounts of human adenoviruses in stools: comparison of a new immuno real-time PCR assay with classical tools. Clin Microbiol Infect 2014; 20(12):O1010-6. doi: 10.1111/1469-0691.12768.
21) Song E, Wang H, Salamon D, Jaggi P, Leber A. Perfor-mance characteristics of FilmArray Respiratory Panel v1.7 for detection of adenovirus in a large cohort of pediatric nasop-haryngeal samples: one test may not fit all. J Clin Microbiol 2016; 54(6):1479-86. doi: 10.1128/JCM.00143-16.
22) Watcharananan S, Avery R, Ingsathit A, Malathum K, Chantratita W, Mavichak V, et al. Adenovirus disease after kid-ney transplantation: course of infection and outcome in relation to blood viral load and immune recovery. Am J Transplant 2011; 11(6):1308-14. doi: 10.1111/j.1600-6143.2011.03479.x.
23) Gniadek T, Forman M, Martin I, Arav-Boger R, Valsamakis A. The effect of a genetic variant on quantitative real-time PCR in a case of disseminated adenovirus infection. Diagn Microbiol Infect Dis 2017; 89(1):40-3. doi: 10.1016/j.diagmicrobio.2017.05.013.
24) Leruez-Ville M, Minard V, Lacaille F, Buzyn A, Abachin E, Blanche S, et al. Real-time blood plasma polymerase chain reaction for management of disseminated adenovirus infection. Clin Infect Dis 2004; 38(1):45-52. doi: 10.1086/380450.
25) Guerra Sánchez C, Lorica C, Arheart K, Perez M, Tekin A, Gonzalez I. Virologic response with 2 different cidofovir dosing regimens for preemptive treatment of adenovirus DNAemia in pediatric solid organ transplant recipients. Pediatr Transplant 2018:e13231. doi: 10.1111/petr.13231.
26) Lankester A, Heemskerk B, Claas E, Schilham M, Beersma M, Bredius R, et al. Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection. Clin In-fect Dis 2004; 38(11):1521-5. doi: 10.1086/420817.
27) López S, Michaels M, Green M. Adenovirus infection in pediatric transplant recipients: are effective antiviral agents coming our way? Curr Opin Organ Transplant 2018; 23(4):395-9. doi: 10.1097/MOT.0000000000000542.
28) Ljungman P. Treatment of adenovirus infections in the immunocompromised host. Eur J Clin Microbiol Infect Dis 2004; 23(8):583-8. doi: 10.1007/s10096-004-1165-x.
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Published
2022-03-14
How to Cite
1.
Prieto J, López M, Noda A, Medina J. Severe adenovirus infections in hepatic transplant recipients. Rev. Méd. Urug. [Internet]. 2022 Mar. 14 [cited 2024 Nov. 22];38(1):e38115. Available from: https://revista.rmu.org.uy/index.php/rmu/article/view/874
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