Localization of subclinical breast lesions with a metal marker (hookwire)
Surgical margins analysis
Keywords:
BREAST NEOPLASMS, SURGICAL DIAGNOSTICS TECHNIQUESAbstract
Introduction: lesion resection with tumor free margins is the objective in breast cancer. If there is a tumor in the surgical margin the rates of recurrence will be higher.
Objectives: to evaluate the experience at the Centro de Diagnóstico Mamario (CENDIMA – Breast Diagnosis Center) of the Asociación Española Primera de Socorros Mutuos, in terms of conservative surgery of breast cancer guided by metal markers. The surgical margins width and the factors associated with the positive margins are studied.
Method: we analysed all cases of subclinical breast cancer treated with conservative surgery guided by metal markers from January 2007 through December 2009 (147 cases).
Results: margins were positive (in contact with the lesion or nearest margin width was up to 1mm) in 39 cases (26%) and negative (width was 22 mm or larger) in 108 cases (74%).
Average lesion size was greater the positive margin cases (15,6 mm compared to 11,4 mm).
An in-situ ductal component was more frequently observed among the positive margins population (82% compares to 42%), and microcalcifications were more frequent in mammographic images (51% compared to 14%). Re-excision due to insufficient margins was performed in 42 cases (29%) and residual tumors were found in 21 of these cases (50%).
Conclusion: the profile of the lesion that is more likely to evidence positive surgical margins after a conservative surgery guided by a metal marker is the following: lesion greater than 10 mm, with an in-situ component in its histology and microcalcification observed in the image.
References
(2) Liberman L, Goodstine SL, Dershaw DD, Morris EA, LaTrenta LR, Abramson AF, et al. One operation after percutaneuos diagnosis of nonpalpable breast cancer: frequency and associated factors. AJR Am J Roentgenol 2002; 178(3): 673-9.
(3) Liberman L, Kaplan J, Van Zee KJ, Morris EA, LaTrenta LR, Abramson AF, et al. Bracketing wires for preoperative breast needle localization. AJR Am J Roentgenol 2001; 177(3): 565-72.
(4) Mokbel K, Ahmed M, Nash A, Sacks N. Re-excision operations in nonpalpable breast cancer. J Surg Oncol 1995; 58(4): 225-8.
(5) Kaufman CS, Delbecq R, Jacobson L. Excising the reexcision: stereotactic core-needle biopsy decreases need for reexcision of breast cancer. World J Surg 1998; 22(10): 1023-8.
(6) Smitt MC, Nowels KW, Zdeblick MJ, Jeffrey S, Carlson RW, Stockdale FE, et al. The importance of the lumpectomy surgical margin status in long-term results of breast conservation. Cancer 1995; 76(2): 259-67.
(7) Dewar JA, Arriagada R, Benhamou S, Benhamou E, Bretel JJ, Pellae-Cosset B, et al. Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982). IGR Breast Cancer Group. Cancer 1995; 76(11): 2260-5.
(8) Morrow M. Margins in breast-conserving therapy: have we lost sight of the big picture? Expert Rev Anticancer Ther 2008; 8(8): 1193-6.
(9) Taghian A, Mohiuddin M, Jagsi R, Goldberg S, Ceilley E, Powell S. Current perceptions regarding surgical margin status after breast-conserving therapy: results of a survey. Ann Surg 2005; 241(4): 629-39.
(10) Azu M, Abrahamse P, Katz SJ, Jagsi R, Morrow M. What is an adequate margin for breast-conserving surgery? Surgeon attitudes and correlates. Ann Surg Oncol 2010; 17(2): 558-63. Epub 2009 Oct 22.
(11) Luini A, Rososchansky J, Gatti G, Zurrida S, Caldarella P, Viale G, et al. The surgical margin status after breast-conserving surgery: discussion of an open issue. Breast Cancer Res Treat 2009; 113(2): 397-402.
(12) Singletary SE. Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy. Am J Surg 2002; 184(5): 383-93.
(13) Walls J, Knox F, Baildam AD, Asbury DL, Mansel RE, Bundred NJ. Can preoperative factors predict for residual malignancy after breast biopsy for invasive cancer? Ann R Coll Surg Engl 1995; 77(4): 248-51.
(14) Pleijhuis RG, Graafland M, de Vries J, Bart J, de Jong JS, van Dam GM. Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions. Ann Surg Oncol 2009; 16(10): 2717-30.
(15) Dillon MF, Hill AD, Quinn CM, McDermott EW, O’Higgins N. A pathologic assessment of adequate margin status in breast-conserving therapy. Ann Surg Oncol 2006; 13(3): 333-9.
(16) Waljee JF, Hu ES, Newman LA, Alderman AK. Predictors of re-excision among women undergoing breast-conserving surgery for cancer. Ann Surg Oncol 2008; 15(5): 1297-303.