The International Registry of Clinical Trials
Article published in: Cuervo LG, Valdés A, Clark ML. The international registry of clinical trials [editorial]. Rev Panam Salud Publica. 2006; 19 (6): 365-70. Available in http://journal.paho.org/index.php?a_ID=510 Authorized for reproduction in the Uruguayan Medical Journal
Abstract
In recent years, a series of particularly notorious scandals has undermined public confidence in clinical research and its results. Specific cases of data manipulation in clinical trial registers and modification of research protocols without justification or without leaving a record have come to light, as well as other reprehensible practices (1). A recent systematic review of the literature revealed, for example, that the results of trials with certain antipsychotic drugs tended to favor the source of funding for the study (2). The adverse impact of such incidents has harmed the entire investigative community, not just those directly responsible. Partial, sometimes deliberate, access to many publicly funded research results has also been censored. As a result, the scientific community has to take steps to restore general confidence in medical research and avoid biases and misrepresentations in the generation and transmission of its results. The registration of all clinical trials in a database that is available to the public is a measure that has been proposed for several years to counteract these trends.
References
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