Idiopathic venous thromboembolic disease as initial manifestation of occult cancer
How ample should the paraclinic screening be for these patients?
Keywords:
VENOUS THROMBOEMBOLISM, NEOPLASMSAbstract
Idiopathic venous thromboembolic disease is a common manifestation of an apparently occult cancer. This scenario is always a challenge for clinical physicians whom must select a diagnostic strategy in order to find this hidden tumor. The aim of this paper is, based on current knowledge, to recommend a scheme of study in an effort to diagnose the majority of the tumors and causing no iatrogenic disease. This review has a brief clinical vignette as a header which seeks only to illustrate a common clinical situation and place the reader in the context it refers. Then, available scientific evidence is reviewed to conceptualize the theoretical framework from which final recommendations emerge.
References
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(10) Monreal M, Lensing AW, Prins MH, Bonet M, Fernández-Llamazares J, Muchart J, et al. Screening for occult cancer in patients with acute deep vein thrombosis or pulmonary embolism. J Thromb Haemost 2004; 2(6): 876-81.
(11) Piccioli A, Lensing AW, Prins MH, Falanga A, Scannapieco GL, Ieran M, et al. Extensive screening for occult malignant disease in idiopathic venous thromboembolism: a prospective randomized clinical trial. J Thromb Haemost 2004; 2(6): 884-9.
(12) Di Nisio M, Otten HM, Piccioli A, Lensing AW, Prandoni P, Büller HR, et al. Decision analysis for cancer screening in idiopathic venous thromboembolism. J Thromb Haemost 2005; 3(11): 2391-6.
(13) Fennerty T. Screening for cancer in venous thromboembolic disease. BMJ 2001; 323(7315): 704-5.
(14) Van Doormaal FF, Terpstra W, Van Der Griend R, Prins MH, Nijziel MR, Van De Ree MA, et al. Is extensive screening for cancer in idiopathic venous thromboembolism warranted? J Thromb Haemost 2011; 9(1): 79-84.
(15) Trujillo-Santos J, Prandoni P, Rivron-Guillot K, Román P, Sánchez R, Tiberio G, et al. Clinical outcome in patients with venous thromboembolism and hidden cancer: findings from the RIETE Registry. J Thromb Haemost 2008; 6(2): 251-5.
(16) Bauer KA, Leung LLK, Landaw SA. Hypercoagulable disorders associated with malignancy. En: Waltham, MA, ed. UpToDate, 2011. Disponible en: http://www.uptodate.com/contents/hypercoagulable-disorders-associated-with-malignancy. Consulta: 2 noviembre 2011.
(2) Levine M. Treatment of thrombotic disorders in cancer patients. Haemostasis 1997; 27(Suppl 1): 38-43.
(3) Murchison JT, Wylie L, Stockton DL. Excess risk of cancer in patients with primary venous thromboembolism: a national, population-based cohort study. Br J Cancer 2004; 91(1): 92-5.
(4) Prandoni P, Piccioli A. Thrombosis as a harbinger of cancer. Curr Opin Hematol 2006, 13(5): 362-5.
(5) White RH, Chew HK, Zhou H, Parikh-Patel A, Harris D, Harvey D, et al. Incidence of venous thromboembolism in the year before the diagnosis of cancer in 528,693 adults. Arch Intern Med 2005; 165(15): 1782-7.
(6) Iodice S, Gandini S, Löhr M, Lowenfels AB, Maisonneuve P. Venous thromboembolic events and organ-specific occult cancers: a review and meta-analysis. J Thromb Haemost 2008; 6(5): 781-8.
(7) Sørensen HT, Mellemkjaer L, Steffensen FH, Olsen JH, Nielsen GL. The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism. N Engl J Med 1998; 338(17): 1169-73.
(8) Sørensen HT, Mellemkjaer L, Olsen JH, Baron JA. Prognosis of cancer associated venous thromboembolism. N Engl J Med 2000; 343(25): 1846-50.
(9) Piccioli A, Prandoni P. Screening for occult cancer in patients with idiopathic venous thromboembolism: yes. J Thromb Haemost 2003; 1(11): 2271-2.
(10) Monreal M, Lensing AW, Prins MH, Bonet M, Fernández-Llamazares J, Muchart J, et al. Screening for occult cancer in patients with acute deep vein thrombosis or pulmonary embolism. J Thromb Haemost 2004; 2(6): 876-81.
(11) Piccioli A, Lensing AW, Prins MH, Falanga A, Scannapieco GL, Ieran M, et al. Extensive screening for occult malignant disease in idiopathic venous thromboembolism: a prospective randomized clinical trial. J Thromb Haemost 2004; 2(6): 884-9.
(12) Di Nisio M, Otten HM, Piccioli A, Lensing AW, Prandoni P, Büller HR, et al. Decision analysis for cancer screening in idiopathic venous thromboembolism. J Thromb Haemost 2005; 3(11): 2391-6.
(13) Fennerty T. Screening for cancer in venous thromboembolic disease. BMJ 2001; 323(7315): 704-5.
(14) Van Doormaal FF, Terpstra W, Van Der Griend R, Prins MH, Nijziel MR, Van De Ree MA, et al. Is extensive screening for cancer in idiopathic venous thromboembolism warranted? J Thromb Haemost 2011; 9(1): 79-84.
(15) Trujillo-Santos J, Prandoni P, Rivron-Guillot K, Román P, Sánchez R, Tiberio G, et al. Clinical outcome in patients with venous thromboembolism and hidden cancer: findings from the RIETE Registry. J Thromb Haemost 2008; 6(2): 251-5.
(16) Bauer KA, Leung LLK, Landaw SA. Hypercoagulable disorders associated with malignancy. En: Waltham, MA, ed. UpToDate, 2011. Disponible en: http://www.uptodate.com/contents/hypercoagulable-disorders-associated-with-malignancy. Consulta: 2 noviembre 2011.
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Published
2012-07-31
How to Cite
1.
Pérez G, Alonso J. Idiopathic venous thromboembolic disease as initial manifestation of occult cancer: How ample should the paraclinic screening be for these patients?. Rev. Méd. Urug. [Internet]. 2012 Jul. 31 [cited 2024 Nov. 22];28(2):148-54. Available from: https://revista.rmu.org.uy/index.php/rmu/article/view/354
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