Idiopathic venous thromboembolic disease as initial manifestation of occult cancer
How ample should the paraclinic screening be for these patients?
Keywords:
VENOUS THROMBOEMBOLISM, NEOPLASMSAbstract
Idiopathic venous thromboembolic disease is a common manifestation of an apparently occult cancer. This scenario is always a challenge for clinical physicians whom must select a diagnostic strategy in order to find this hidden tumor. The aim of this paper is, based on current knowledge, to recommend a scheme of study in an effort to diagnose the majority of the tumors and causing no iatrogenic disease. This review has a brief clinical vignette as a header which seeks only to illustrate a common clinical situation and place the reader in the context it refers. Then, available scientific evidence is reviewed to conceptualize the theoretical framework from which final recommendations emerge.
References
(1) Bülller HR. Has time come for screening for occult cancer in patients with venous thromboembolism? J Thromb Haemost 2004; 2(6): 874-5.
(2) Levine M. Treatment of thrombotic disorders in cancer patients. Haemostasis 1997; 27(Suppl 1): 38-43.
(3) Murchison JT, Wylie L, Stockton DL. Excess risk of cancer in patients with primary venous thromboembolism: a national, population-based cohort study. Br J Cancer 2004; 91(1): 92-5.
(4) Prandoni P, Piccioli A. Thrombosis as a harbinger of cancer. Curr Opin Hematol 2006, 13(5): 362-5.
(5) White RH, Chew HK, Zhou H, Parikh-Patel A, Harris D, Harvey D, et al. Incidence of venous thromboembolism in the year before the diagnosis of cancer in 528,693 adults. Arch Intern Med 2005; 165(15): 1782-7.
(6) Iodice S, Gandini S, Löhr M, Lowenfels AB, Maisonneuve P. Venous thromboembolic events and organ-specific occult cancers: a review and meta-analysis. J Thromb Haemost 2008; 6(5): 781-8.
(7) Sørensen HT, Mellemkjaer L, Steffensen FH, Olsen JH, Nielsen GL. The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism. N Engl J Med 1998; 338(17): 1169-73.
(8) Sørensen HT, Mellemkjaer L, Olsen JH, Baron JA. Prognosis of cancer associated venous thromboembolism. N Engl J Med 2000; 343(25): 1846-50.
(9) Piccioli A, Prandoni P. Screening for occult cancer in patients with idiopathic venous thromboembolism: yes. J Thromb Haemost 2003; 1(11): 2271-2.
(10) Monreal M, Lensing AW, Prins MH, Bonet M, Fernández-Llamazares J, Muchart J, et al. Screening for occult cancer in patients with acute deep vein thrombosis or pulmonary embolism. J Thromb Haemost 2004; 2(6): 876-81.
(11) Piccioli A, Lensing AW, Prins MH, Falanga A, Scannapieco GL, Ieran M, et al. Extensive screening for occult malignant disease in idiopathic venous thromboembolism: a prospective randomized clinical trial. J Thromb Haemost 2004; 2(6): 884-9.
(12) Di Nisio M, Otten HM, Piccioli A, Lensing AW, Prandoni P, Büller HR, et al. Decision analysis for cancer screening in idiopathic venous thromboembolism. J Thromb Haemost 2005; 3(11): 2391-6.
(13) Fennerty T. Screening for cancer in venous thromboembolic disease. BMJ 2001; 323(7315): 704-5.
(14) Van Doormaal FF, Terpstra W, Van Der Griend R, Prins MH, Nijziel MR, Van De Ree MA, et al. Is extensive screening for cancer in idiopathic venous thromboembolism warranted? J Thromb Haemost 2011; 9(1): 79-84.
(15) Trujillo-Santos J, Prandoni P, Rivron-Guillot K, Román P, Sánchez R, Tiberio G, et al. Clinical outcome in patients with venous thromboembolism and hidden cancer: findings from the RIETE Registry. J Thromb Haemost 2008; 6(2): 251-5.
(16) Bauer KA, Leung LLK, Landaw SA. Hypercoagulable disorders associated with malignancy. En: Waltham, MA, ed. UpToDate, 2011. Disponible en: http://www.uptodate.com/contents/hypercoagulable-disorders-associated-with-malignancy. Consulta: 2 noviembre 2011.
(2) Levine M. Treatment of thrombotic disorders in cancer patients. Haemostasis 1997; 27(Suppl 1): 38-43.
(3) Murchison JT, Wylie L, Stockton DL. Excess risk of cancer in patients with primary venous thromboembolism: a national, population-based cohort study. Br J Cancer 2004; 91(1): 92-5.
(4) Prandoni P, Piccioli A. Thrombosis as a harbinger of cancer. Curr Opin Hematol 2006, 13(5): 362-5.
(5) White RH, Chew HK, Zhou H, Parikh-Patel A, Harris D, Harvey D, et al. Incidence of venous thromboembolism in the year before the diagnosis of cancer in 528,693 adults. Arch Intern Med 2005; 165(15): 1782-7.
(6) Iodice S, Gandini S, Löhr M, Lowenfels AB, Maisonneuve P. Venous thromboembolic events and organ-specific occult cancers: a review and meta-analysis. J Thromb Haemost 2008; 6(5): 781-8.
(7) Sørensen HT, Mellemkjaer L, Steffensen FH, Olsen JH, Nielsen GL. The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism. N Engl J Med 1998; 338(17): 1169-73.
(8) Sørensen HT, Mellemkjaer L, Olsen JH, Baron JA. Prognosis of cancer associated venous thromboembolism. N Engl J Med 2000; 343(25): 1846-50.
(9) Piccioli A, Prandoni P. Screening for occult cancer in patients with idiopathic venous thromboembolism: yes. J Thromb Haemost 2003; 1(11): 2271-2.
(10) Monreal M, Lensing AW, Prins MH, Bonet M, Fernández-Llamazares J, Muchart J, et al. Screening for occult cancer in patients with acute deep vein thrombosis or pulmonary embolism. J Thromb Haemost 2004; 2(6): 876-81.
(11) Piccioli A, Lensing AW, Prins MH, Falanga A, Scannapieco GL, Ieran M, et al. Extensive screening for occult malignant disease in idiopathic venous thromboembolism: a prospective randomized clinical trial. J Thromb Haemost 2004; 2(6): 884-9.
(12) Di Nisio M, Otten HM, Piccioli A, Lensing AW, Prandoni P, Büller HR, et al. Decision analysis for cancer screening in idiopathic venous thromboembolism. J Thromb Haemost 2005; 3(11): 2391-6.
(13) Fennerty T. Screening for cancer in venous thromboembolic disease. BMJ 2001; 323(7315): 704-5.
(14) Van Doormaal FF, Terpstra W, Van Der Griend R, Prins MH, Nijziel MR, Van De Ree MA, et al. Is extensive screening for cancer in idiopathic venous thromboembolism warranted? J Thromb Haemost 2011; 9(1): 79-84.
(15) Trujillo-Santos J, Prandoni P, Rivron-Guillot K, Román P, Sánchez R, Tiberio G, et al. Clinical outcome in patients with venous thromboembolism and hidden cancer: findings from the RIETE Registry. J Thromb Haemost 2008; 6(2): 251-5.
(16) Bauer KA, Leung LLK, Landaw SA. Hypercoagulable disorders associated with malignancy. En: Waltham, MA, ed. UpToDate, 2011. Disponible en: http://www.uptodate.com/contents/hypercoagulable-disorders-associated-with-malignancy. Consulta: 2 noviembre 2011.
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Published
2012-07-31
How to Cite
1.
Pérez G, Alonso J. Idiopathic venous thromboembolic disease as initial manifestation of occult cancer: How ample should the paraclinic screening be for these patients?. Rev. Méd. Urug. [Internet]. 2012 Jul. 31 [cited 2024 Sep. 7];28(2):148-54. Available from: https://revista.rmu.org.uy/index.php/rmu/article/view/354
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