Importancia de las hipocretinas en la patogenia de la narcolepsia

Autores/as

  • Pablo Torterolo Universidad de la República, Facultad de Medicina, Departamento de Fisiología, Fisiología, Profesor Adjunto
  • Giancarlo Vanini Universidad de la República, Facultad de Medicina, Departamento de Fisiología, Fisiología, Asistente. Medicina Intensiva, Residente

Palabras clave:

NARCOLEPSIA, CATAPLEXIA, NEUROPÉPTIDOS, SUEÑO, VIGILIA, SUEÑO REM, HIPOTÁLAMO

Resumen

La hipocretina 1 e hipocretina 2 son neuromoduladores peptídicos que se encuentran en neuronas cuyos somas están localizados en el hipotálamo. Estas neuronas proyectan a diversas regiones del sistema nervioso central. Recientemente se ha descubierto que la alteración de este sistema (sistema hipocretinérgico) se vincula íntimamente con la patogenia de la narcolepsia. Este trabajo pretende hacer una breve reseña de la relación de las hipocretinas con la narcolepsia, así como de la importancia de éstas en la regulación del ciclo sueño-vigilia.

Citas

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Publicado

2003-05-30

Cómo citar

1.
Torterolo P, Vanini G. Importancia de las hipocretinas en la patogenia de la narcolepsia. Rev. Méd. Urug. [Internet]. 30 de mayo de 2003 [citado 19 de mayo de 2024];19(1):27-33. Disponible en: https://revista.rmu.org.uy/index.php/rmu/article/view/953

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