Progesterona para el tratamiento del trauma craneoencefálico grave

una revisión sistemática y metaanálisis

  • William Flórez Perdomo Colombia, Clínica Sahagún IPS , Departamento de Urgencias.
  • Miguel Durán Colombia, Universidad Surcolombiana, Médico general.
  • Edgar F Laiseca Colombia, Universidad Surcolombiana, Médico general.
  • Sergio A Serrato
  • Mario F Quesada Colombia. Fundación Universitaria Navarra.


Objetivo: revisar sistemáticamente la evidencia sobre la administración de progesterona tras un trauma craneoencefálico grave en adultos y su relación con mortalidad y pronóstico neurológico.
Criterios de inclusión: ensayos clínicos aleatorizados que incluyan a pacientes adultos mayores de 18 años, haber sufrido un traumatismo craneal grave (Glasgow <8), donde se compare la administración de progesterona vs grupo control (placebo o no administración).
Método: se realizó la búsqueda en las siguientes bases de datos: MEDLINE, the Central Register of Controlled Trials (CENTRAL); PubMed, HINARI, EMBASE; Cochrane Injuries group y lista de referencia de los artículos.
Resultados: no hubo reducción de la mortalidad comparado con el grupo control (RR 0,93, IC95% 0,79-1,10 p= 0,41), no hubo diferencias entre progesterona y el grupo control en desenlaces neurológicos positivos ni negativos (RR 1,07, IC95% 0,97-1,17 p= 0,20; RR 0,94, IC 95% 0,81-1,08 p= 0,27), respectivamente.
Conclusiones: no se encontró evidencia respecto a que la administración de progesterona posterior a un traumatismo craneoencefálico reduzca la mortalidad o mejore desenlaces neurológicos, aunque se necesitan más estudios de buena calidad para extraer conclusiones definitivas.


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Cómo citar
Flórez Perdomo W, Durán M, Laiseca EF, Serrato SA, Quesada MF. Progesterona para el tratamiento del trauma craneoencefálico grave. Rev. Méd. Urug. [Internet]. 31 de marzo de 2020 [citado 8 de abril de 2020];36(1):74-. Disponible en:
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