Tamizaje del cáncer de cuello uterino con test de HVP

Primeros resultados en el sistema público de Uruguay

Palabras clave: NEOPLASIAS DEL CUELLO UTERINO, INFECCIONES POR PAPILLOMAVIRUS, PRUEBA DE PAPANICOLAOU, CRIBADO, PREVENCIÓN SECUNDARIA

Resumen

Introduccción: en Uruguay, el cáncer de cuello uterino ocupó el tercer lugar con una incidencia promedio de 312 nuevos casos por año; fallecieron 134 mujeres promedio por año en el período 2010 - 2014.
Objetivo: el objetivo de este trabajo fue analizar los primeros resultados de una experiencia piloto con la aplicación del test de HPV captura híbrida HC2 (QiagenR ) como test de tamizaje primario del cáncer de cuello uterino en una zona del departamento de Canelones.
Método: se estudiaron 1.010 mujeres asintomáticas entre 30 y 64 años que concurrieron a realizarse el test de PAP a dos unidades de toma de muestras del Programa de prevención del cáncer de cuello uterino. Se realizó la extracción conjunta de la muestra para PAP, que fue derivada a uno de los laboratorios de citología de la Red de Atención Primaria de Salud y la muestra de HPV que fue procesada con la técnica de captura híbrida en el laboratorio de biología molecular del Centro Hospitalario Pereira Rossell. Las usuarias con resultados HPV + y PAP anormales (ASC-US+) fueron derivadas a colposcopia, con biopsia y posterior tratamiento cuando correspondió.
Resultados: el test de HPV fue positivo en 126/1.010 mujeres (12,5%) y el PAP anormal en 167/1.010 (16,5%). El test de HPV fue positivo en todos los casos CIN2+ 13/13 (100%) mientras que el PAP fue anormal (ASCUS+) en 7/13 (54%) para CIN2+ por biopsia.
Conclusión: el test de HPV resultó más eficaz y eficiente que el PAP para la detección de lesiones precancerosas de cuello uterino.

Citas

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Publicado
2019-11-04
Cómo citar
1.
Rodríguez G, García L, Beracochea A, Alonso R, Caserta B, Pérez N, Larrosa D, Vero MJ, Ardao G, Santos MN, Hernández ML, Almonte M, Herrero R, Uruguay GE. Tamizaje del cáncer de cuello uterino con test de HVP. Rev. Méd. Urug. [Internet]. 4 de noviembre de 2019 [citado 17 de noviembre de 2019];35(4):267-80. Disponible en: https://revista.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/304
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