Utilidad del ensayo de cadenas livianas libres en suero en el manejo de gammapatías monoclonales

Diagnóstico, pronóstico y monitoreo

  • María Florencia Delgado The Binding Site Group Ltd. Latin America. Scientific Affairs Manager
Palabras clave: CADENAS LIGERAS DE INMUNOGLOBULINA, PARAPROTEINEMIAS, MIELOMA MÚLTIPLE, AMILOIDOSIS

Resumen

El ensayo de cadenas livianas libres en suero cuantifica los niveles de κ y λ libres. Existen tres indicaciones principales para la medición de cadenas livianas libres en el manejo de pacientes con mieloma múltiple y enfermedades relacionadas. Primero, en el contexto del diagnóstico, donde en combinación con la electroforesis de proteínas en suero y la inmunofijación en suero proporcionan el esquema de tamizaje de mayor sensibilidad, eliminando la necesidad de analizar la orina de 24 horas. Segundo, los valores basales de cadenas livianas libres en suero han mostrado tener valor pronóstico para la mayoría de las gammapatías monoclonales. Tercero, el ensayo de cadenas livianas libres en suero permite un monitoreo cuantitativo y sensible en pacientes con presentación oligosecretora de la enfermedad, incluyendo la AL amiloidosis y cerca del 70% de los pacientes históricamente denominados no secretores. Esta revisión tiene por objeto actualizar la información sobre las aplicaciones de esta importante prueba.

Citas

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Publicado
2014-03-31
Cómo citar
1.
Delgado MF. Utilidad del ensayo de cadenas livianas libres en suero en el manejo de gammapatías monoclonales. Rev. Méd. Urug. [Internet]. 31 de marzo de 2014 [citado 6 de junio de 2020];30(1):65-. Disponible en: http://revista.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/261
Sección
Trabajos de Revisión o Actualización y Puestas al día